Searchable abstracts of presentations at key conferences in endocrinology

ea0081p639 | Endocrine-Related Cancer | ECE2022

Does the length of a polyalanine tract in the FOXE1 gene impact the course of familial non-medullary thyroid cancer?

Domagała Bartosz , Koziara Michał , Trofimiuk-Muldner Malgorzata , Skalniak Anna , Hubalewska-Dydejczyk Alicja

Familial non-medullary thyroid cancer (FNMTC) constitutes about 3–9% of all thyroid cancers. One of the genes believed to predispose to non-syndromic FNMTC is FOXE1. It contains a polyalanine tract (polyAla) with a variable number (11 – 22) of alanine residues. This length polymorphism could lead to changes in the FOXE1-encoded protein (FOXE1 transcription factor) structure and predispose to papillary thyroid cancer (PTC). The aim of the st...