ea0081p639 | Endocrine-Related Cancer | ECE2022
Domagała Bartosz
, Koziara Michał
, Trofimiuk-Muldner Malgorzata
, Skalniak Anna
, Hubalewska-Dydejczyk Alicja
Familial non-medullary thyroid cancer (FNMTC) constitutes about 39% of all thyroid cancers. One of the genes believed to predispose to non-syndromic FNMTC is FOXE1. It contains a polyalanine tract (polyAla) with a variable number (11 22) of alanine residues. This length polymorphism could lead to changes in the FOXE1-encoded protein (FOXE1 transcription factor) structure and predispose to papillary thyroid cancer (PTC). The aim of the st...